Bio: Edward Dennis is a chemistry and biochemistry professor in UCSD's Division of Physical Sciences and UCSD's School of Medicine.
Research: Our laboratory is focused on understanding the regulation of lipid second messengers and signal transduction processes and especially the role of various phospholipases in their generation. Special attention is paid to the cytosolic, secreted, and membrane-bound phospholipase A2s (PLA2) responsible for the control of prostaglandin and leukotriene biosynthesis in macrophage cells. These are produced from arachidonic acid released by PLA2 upon cell stimulation. Our goal is to characterize and elucidate the regulatory mechanisms of various phospholipase A2s both in vitro and in the intact cell.